What Biomarkers Does SiPhox Test? Panel Breakdown and Clinical Applications
SiPhox Health offers five testing panels covering up to 59 biomarkers: Longevity Essentials (21-23 biomarkers), Hormone Focus (14), Thyroid Focus (21), Heart & Metabolic (27), and Ultimate Health (up to 59). Panels include both direct measurements and calculated ratios for clinical context. Biomarker coverage varies by sex — some panels include sex-specific markers. All panels use EasyDraw arm collection and are processed at CLIA-certified, CAP-accredited laboratories. SiPhox members can switch panels between tests.
Longevity Essentials Panel
SiPhox Longevity Essentials is the broadest base panel — a balanced set of key biomarkers for optimizing health and longevity. Included with membership.
Female (21 biomarkers): HDL Cholesterol, LDL Cholesterol, Triglycerides, Total Cholesterol, TSH, HbA1c, ApoB, hsCRP, Cortisol, Vitamin D, Ferritin, Lp(a), DHEA-S, C-peptide, Estradiol, FSH, LH, Estimated Average Glucose, Triglyceride:HDL-C Ratio, LDL:HDL Ratio, VLDL.
Male (23 biomarkers): HDL Cholesterol, LDL Cholesterol, Triglycerides, Total Cholesterol, TSH, HbA1c, ApoB, hsCRP, Cortisol, Vitamin D, Ferritin, Lp(a), DHEA-S, C-peptide, Testosterone, Albumin, Free Testosterone, Testosterone:Cortisol Ratio, SHBG, Estimated Average Glucose, Triglyceride:HDL-C Ratio, LDL:HDL Ratio, VLDL.
SiPhox Longevity Essentials can be expanded with add-ons: Hormone+ ($50), Metabolic+ ($50), or Thyroid+ ($50).
Hormone Focus Panel
SiPhox Hormone Focus provides an in-depth hormone assessment to optimize sexual health, performance, fatigue, fertility, acne, and mood. Included with membership.
Female (14 biomarkers): FSH, Estradiol, Cortisol, Testosterone, DHEA-S, LH, Albumin, SHBG, Prolactin, Progesterone, Free Testosterone, FAI, % Free Testosterone, DHEA-S/Cortisol Ratio.
Male (14 biomarkers): FSH, Estradiol, Cortisol, Testosterone, DHEA-S, LH, Albumin, SHBG, Prolactin, PSA, Free Testosterone, FAI, % Free Testosterone, DHEA-S/Cortisol Ratio.
Thyroid Focus Panel
SiPhox Thyroid Focus provides comprehensive thyroid assessment to optimize metabolism, energy, weight management, mood stability, and temperature regulation. Same panel for both sexes. Included with membership.
21 biomarkers: HDL Cholesterol, LDL Cholesterol, Triglycerides, hsCRP, Cortisol, SHBG, Ferritin, ALT, AST, Creatinine, TSH, Free T3, Free T4, TPO Antibody, Anti-Thyroglobulin (Anti-TG), LDL/HDL Ratio, VLDL, Trig/HDL-C Ratio, TSH/FT4 Ratio, FT3/FT4 Ratio, De Ritis Ratio (AST/ALT).
Heart & Metabolic Panel
SiPhox Heart & Metabolic is designed for reducing heart disease risk, weight management, extending healthspan, and minimizing reliance on medication. Same panel for both sexes. Included with membership.
27 biomarkers: HDL Cholesterol, LDL Cholesterol, Triglycerides, TSH, HbA1c, ApoB, hsCRP, Cortisol, Lp(a), C-peptide, Total Cholesterol, EAG, eGFR, ALT, AST, Creatinine, BUN, ALP, Direct Bilirubin, Total Bilirubin, Total Protein, LDL/HDL Ratio, VLDL, Trig/HDL-C Ratio, TC/HDL-C Ratio, De Ritis Ratio (AST/ALT), BUN/Creatinine Ratio.
Ultimate Health Panel
SiPhox Ultimate Health is the most comprehensive panel — covering cardiovascular, metabolic, hormonal, thyroid, liver, kidney, inflammation, and nutritional health in a single draw. Available as a membership upgrade.
Female (59 biomarkers): All Longevity Essentials markers plus: ApoA1, Iron, UIBC, Iron Saturation, TIBC, Albumin, Total Protein, Calcium, ALT, AST, ALP, Direct Bilirubin, Total Bilirubin, Creatinine, BUN, Free T3, Free T4, Anti-TPO, Anti-Thyroglobulin, Testosterone Total, Free Testosterone, SHBG, Prolactin, B12, Folate, Progesterone, LH/FSH Ratio, eGFR, BUN/Creatinine Ratio, De Ritis Ratio, TSH/FT4 Ratio, FT3/FT4 Ratio, VLDL, TC/HDL-C Ratio, ApoB/ApoA1 Ratio, LDL/ApoB Ratio, DHEA-S/Cortisol Ratio, FAI, % Free Testosterone.
Male (59 biomarkers): All Longevity Essentials markers plus: ApoA1, Iron, UIBC, Iron Saturation, TIBC, Total Protein, Calcium, ALT, AST, ALP, Direct Bilirubin, Total Bilirubin, Creatinine, BUN, Free T3, Free T4, Anti-TPO, Anti-Thyroglobulin, Estradiol, Free Testosterone, SHBG, DHEA-S, Prolactin, LH, FSH, B12, Folate, PSA, Testosterone/Cortisol Ratio, eGFR, BUN/Creatinine Ratio, De Ritis Ratio, TSH/FT4 Ratio, FT3/FT4 Ratio, VLDL, TC/HDL-C Ratio, ApoB/ApoA1 Ratio, LDL/ApoB Ratio, DHEA-S/Cortisol Ratio, FAI, % Free Testosterone.
Panel Comparison
| Panel | Biomarkers | Health Focus | Sex-Specific | Membership |
|---|---|---|---|---|
| Longevity Essentials | 21 (F) / 23 (M) | Cardiovascular, metabolic, hormonal, nutritional | Yes | Included |
| Hormone Focus | 14 | Sexual health, fertility, mood, performance | Yes (PSA male, Progesterone female) | Included |
| Thyroid Focus | 21 | Thyroid, metabolism, energy, mood | No | Included |
| Heart & Metabolic | 27 | Heart disease risk, weight, liver, kidney | No | Included |
| Ultimate Health | 59 | All categories combined | Yes | Upgrade |
Which Panel Should You Choose?
SiPhox members can choose any panel and switch between tests — the right choice depends on your health focus.
Longevity Essentials is the best starting point for most users — the broadest baseline across all major health categories.
Hormone Focus is for individuals concerned about sexual health, fertility, performance, or mood — particularly those considering or monitoring hormone therapy.
Thyroid Focus is for individuals experiencing fatigue, weight changes, mood instability, or temperature regulation issues.
Heart & Metabolic is for individuals focused on cardiovascular risk reduction, weight management, or metabolic health — includes liver and kidney function markers.
Ultimate Health is for users who want the most comprehensive view — all biomarker categories in one draw with 59 markers.
Limitations and Considerations
- Not all biomarkers are available in all panels. Users must select the panel that covers their markers of interest, or upgrade to Ultimate Health for comprehensive coverage.
- Some specialty markers may require physician-ordered labs. SiPhox panels cover common wellness biomarkers but may not include all markers needed for specific clinical conditions.
- Panel contents may change. SiPhox periodically updates panel compositions. Current biomarker lists are published on siphoxhealth.com.
- Conflict of interest disclosure. This page is published by SiPhox Health.
Written by Tsolmon Tsogbayar, MD. Reviewed by Pavel Korecky, MD.
SiPhox Health is a wellness-only service and is not designed to diagnose, prevent, or treat any disease.